How and where to order Diazepam (Valium) 10 mg tablets or capsules online on Test-Taking Anxiety website:
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Diazepam (trade names include Valium, Antenex, Anxicalm, Apaurin, Apo-Diazepam, Betapam, Calmpose, Diazepam Desitin, Diazepam Ratiopharm, Diazepam Sandoz, Gewacalm, Hexalid, Lembrol, Manodiazo, Paceum, Placidox, Relanium, Stesolid, Unisedil, Valpam, Zepose) is an anxiolytic medication from benzodiazepine derivatives pharmacological group. This medicine is used for the treatment of anxiety disorders, short-term relief of the symptoms of anxiety, panic attacks, states of agitation, to relieve nervousness and tension, neurovegetative symptoms associated with vertigo, sleep disturbances, insomnia, cause memory loss, restless legs syndrome, tetanus, eclampsia. It is also indicated to treat muscle spasms, spastic muscular paresis, stiff person syndrome, benzodiazepine withdrawal syndrome, symptoms of opiate and alcohol withdrawal such as tremors. In some cases Diazepam may be prescribed as anticonvulsant for the management symptoms of seizures, or as skeletal muscle relaxant.
Clorazepate Dipotassium (Tranxene)
Ethyl Loflazepate (Victan)
Pharmacological and medical categories:
Hypnotics and sedatives
Skeletal muscle relaxant
N - Nervous system
N05 - Psycholeptics
N05B - Anxiolytics
N05BA - Benzodiazepine derivatives
N05BA01 - Diazepam
Other tetanus - A35
Mental and behavioural disorders due to use of alcohol - F10
Unspecified nonorganic psychosis - F29
Phobic anxiety disorders - F40
Other anxiety disorders - F41
Somatoform disorders - F45
Other neurotic disorders - F48
Nonorganic sleep disorders - F51
Disorders of social functioning with onset specific to childhood and adolescence - F94
Tic disorders - F95
Other behavioural and emotional disorders with onset usually occurring in childhood and adolescence - F98
Dystonia - G24
Epilepsy - G40
Status epilepticus - G41
Hemiplegia - G81
Paraplegia and tetraplegia - G82
Menopausal and other perimenopausal disorders - N95
Eclampsia - O15
Abnormal involuntary movements - R25
Other symptoms and signs involving the nervous and musculoskeletal systems - R29
Other medical care - Z51
Indications and usage:
Valium (Diazepam) is indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.
In acute alcohol withdrawal, Valium may be useful in the symptomatic relief of acute agitation, tremor, impending or acute delirium tremens and hallucinosis.
Diazepam is a useful adjunct for the relief of skeletal muscle spasm due to reflex spasm to local pathology (such as inflammation of the muscles or joints, or secondary to trauma), spasticity caused by upper motor neuron disorders (such as cerebral palsy and paraplegia), athetosis, and stiff-man syndrome.
Oral Valium may be used adjunctively in convulsive disorders, although it has not proved useful as the sole therapy.
The effectiveness of Valium in long-term use, that is, more than 4 months, has not been assessed by systematic clinical studies. The physician should periodically reassess the usefulness of the drug for the individual patient.
Dosage and administration:
Dosage should be individualized for maximum beneficial effect. While the usual daily dosages given below will meet the needs of most patients, there will be some who may require higher doses. In such cases dosage should be increased cautiously to avoid adverse effects.
Management of anxiety disorders and relief of symptoms of anxiety: Depending upon severity of symptoms - 2 mg to 10 mg, 2 to 4 times daily.
Symptomatic relief in acute alcohol withdrawal: 10 mg, 3 or 4 times during the first 24 hours, reducing to 5 mg, 3 or 4 times daily as needed.
Adjunctively for relief of skeletal muscle spasm: 2 mg to 10 mg, 3 or 4 times daily.
Adjunctively in convulsive disorders: 2 mg to 10 mg, 2 to 4 times daily
Geriatric patients, or in the presence of debilitating disease: mg to 2.5 mg, 1 or 2 times daily initially; increase gradually as needed and tolerated.
Because of varied responses to CNS-acting drugs, initiate therapy with lowest dose and increase as required. Not for use in pediatric patients under 6 months: 1 mg to 2.5 mg, 3 or 4 times daily initially; increase gradually as needed and tolerated.
Overdose of benzodiazepines including diazepam is usually manifested by central nervous system depression ranging from drowsiness to coma. In mild cases, symptoms include drowsiness, confusion, and lethargy. In more serious cases, symptoms may include ataxia, diminished reflexes, hypotonia, hypotension, respiratory depression, coma (rarely), and death (very rarely). Overdose of benzodiazepines in combination with other CNS depressants (including alcohol) may be fatal and should be closely monitored.
Dosage forms and strengths:
For oral administration, Valium is supplied as round, flat-faced scored tablets with V-shaped perforation and beveled edges. Valium is available as follows: 2 mg, white; 5 mg, yellow; 10 mg, blue.
Engraved on tablets:
2 mg - 2 Valium (front) Roche (twice on scored side)
5 mg - 5 Valium (front) Roche (twice on scored side)
10 mg - 10 Valium (front) Roche (twice on scored side).
Valium (Diazepam) is contraindicated in patients with a known hypersensitivity to diazepam and, because of lack of sufficient clinical experience, in pediatric patients under 6 months of age. Valium is also contraindicated in patients with myasthenia gravis, severe respiratory insufficiency, severe hepatic insufficiency, and sleep apnea syndrome. It may be used in patients with open-angle glaucoma who are receiving appropriate therapy, but is contraindicated in acute narrow-angle glaucoma.
Concomitant use of benzodiazepiones, including Valium, and opioids may result in profound sedation, respiratory depression, coma, and death. Because of these risks, reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate.
Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to use of opioids alone. If a decision is made to prescribe Valium concomitantly with opioids, prescribe the lowest effective dosages and minimum durations of concomitant use, and follow patients closely for signs and symptoms of respiratory depression and sedation. In patients already receiving an opioid analgesic, prescribe a lower initial dose of Valium than indicated in the absence of an opioid and titrate based on clinical response. If an opioid is initiated in a patient already taking Valium, prescribe a lower initial dose of the opioid and titrate based upon clinical response.
Advise both patients and caregivers about the risks of respiratory depression and sedation when Valium is used with opioids. Advise patients not to drive or operate heavy machinery until the effects of concomitant use with the opioid have been determined.
Diazepam is not recommended in the treatment of psychotic patients and should not be employed instead of appropriate treatment.
Since this drug has a central nervous system depressant effect, patients should be advised against the simultaneous ingestion of alcohol and other CNS-depressant drugs during Valium therapy.
As with other agents that have anticonvulsant activity, when Valium is used as an adjunct in treating convulsive disorders, the possibility of an increase in the frequency and/or severity of grand mal seizures may require an increase in the dosage of standard anticonvulsant medication. Abrupt withdrawal of diazepam in such cases may also be associated with a temporary increase in the frequency and/or severity of seizures.
If Valium (Diazepam) is to be combined with other psychotropic agents or anticonvulsant drugs, careful consideration should be given to the pharmacology of the agents to be employed - particularly with known compounds that may potentiate the action of diazepam, such as phenothiazines, narcotics, barbiturates, MAO inhibitors and other antidepressants.
The usual precautions are indicated for severely depressed patients or those in whom there is any evidence of latent depression or anxiety associated with depression, particularly the recognition that suicidal tendencies may be present and protective measures may be necessary.
Psychiatric and paradoxical reactions are known to occur when using benzodiazepines. Should this occur, use of the drug should be discontinued. These reactions are more likely to occur in children and the elderly.
A lower dose is recommended for patients with chronic respiratory insufficiency, due to the risk of respiratory depression.
Benzodiazepines should be used with extreme caution in patients with a history of alcohol or drug abuse.
In debilitated patients, it is recommended that the dosage be limited to the smallest effective amount to preclude the development of ataxia or oversedation (2 mg to 2.5 mg once or twice daily, initially, to be increased gradually as needed and tolerated).
Some loss of response to the effects of benzodiazepines may develop after repeated use of diazepam for a prolonged time.
Adverse reactions, side effects:
Most commonly reported side effects of Diazepam (Valium) tablets were:
The concomitant use of benzodiazepines and opioids increases the risk of respiratory depression because of actions at different receptor sites in the CNS that control respiration. Benzodiazepines interact at GABAA sites and opioids interact primarily at mu receptors. When benzodiazepines and opioids are combined, the potential for benzodiazepines to significantly worsen opioid-related respiratory depression exists. Limit dosage and duration of concomitant use of benzodiazepines and opioids, and monitor patients closely for respiratory depression and sedation.
Centrally Acting Agents
If Valium (Diazepam) is to be combined with other centrally acting agents, careful consideration should be given to the pharmacology of the agents employed particularly with compounds that may potentiate or be potentiated by the action of Valium, such as phenothiazines, antipsychotics, anxiolytics/sedatives, hypnotics, anticonvulsants, narcotic analgesics, anesthetics, sedative antihistamines, narcotics, barbiturates, MAO inhibitors and other antidepressants.
Concomitant use with alcohol is not recommended due to enhancement of the sedative effect.
Diazepam peak concentrations are 30% lower when antacids are administered concurrently. However, there is no effect on the extent of absorption. The lower peak concentrations appear due to a slower rate of absorption, with the time required to achieve peak concentrations on average 20 - 25 minutes greater in the presence of antacids. However, this difference was not statistically significant.
Compounds which inhibit certain hepatic enzymes
There is a potentially relevant interaction between diazepam and compounds which inhibit certain hepatic enzymes (particularly cytochrome P450 3A and 2C19). Data indicate that these compounds influence the pharmacokinetics of diazepam and may lead to increased and prolonged sedation. At present, this reaction is known to occur with cimetidine, ketoconazole, fluvoxamine, fluoxetine, and omeprazole.
There have also been reports that the metabolic elimination of phenytoin is decreased by diazepam.
Use in specific populations:
Safety and effectiveness of diazepam in pediatric patients below the age of 6 months have not been established.
In elderly patients, it is recommended that the dosage be limited to the smallest effective amount to preclude the development of ataxia or oversedation (2 mg to 2.5 mg once or twice daily, initially to be increased gradually as needed and tolerated).
Extensive accumulation of diazepam and its major metabolite, desmethyldiazepam, has been noted following chronic administration of diazepam in healthy elderly male subjects. Metabolites of this drug are known to be substantially excreted by the kidney, and the risk of toxic reactions may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
Decreases in clearance and protein binding, and increases in volume of distribution and half-life have been reported in patients with cirrhosis. In such patients, a 2- to 5- fold increase in mean half-life has been reported. Delayed elimination has also been reported for the active metabolite desmethyldiazepam. Benzodiazepines are commonly implicated in hepatic encephalopathy. Increases in half-life have also been reported in hepatic fibrosis and in both acute and chronic hepatitis.
C - Australia
D - United States (Positive evidence of risk)
Salts and other forms:
Synonyms, international and chemical names:
Brands, generics, trade names:
Alboral - Silanes Laboratorios
Ansilive - Libbs Farmaceutica
Ansiolin - Almirall
Antenex - Alphapharm
Anxicalm - Clonmel Healthcare
Apaurin - KRKA
Apo-Diazepam - Apotex
Assival - Teva
Betapam - Be-Tabs Pharmaceuticals
Calmpose - Ranbaxy
Diapam - Greater Pharma, Orion Pharma
Diazemuls - Pfizer, Actavis, Alpharma, CSL, Primal Chemical, Teva
Diazep - CT-Arzneimittel, AbZ-Pharma
Diazepam - Desitin Arzneimittel, IVAX, Mylan, Ratiopharm, Sandoz, Stada, Teva
Faustan - Temmler Pharma
Gewacalm - Nycomed
Hexalid - Sandoz
Kratium - Medochemie, Star Medical Supplies
Lembrol - Sanofi-Aventis
Manodiazo - March Pharmaceuticals
Medipam - Ratiopharm
Paceum - Orion Pharma
Paxum - East India Pharmaceutical Works
Placidox - Lupin Pharmaceuticals
Plidan - Roemmers Laboratorios
Psychopax - Sigmapharm Arzneimittel, Proreo Pharma, Ridupharm
Relanium - Polfa Warszawa
Seredyn - Degort's Chemical
Stesolid - Alpharma
Tranquirit - Sanofi-Aventis
Unisedil - Merck
Valiquid - Roche
Valisanbe - Sanbe Farma
Valium - Roche
Valocordin-Diazepam - Krewel Meuselbach
Valpam - Arrow Pharmaceuticals
Valrelease - Roche
Zepose - Cipla
APIs used in medicine in combinations with diazepam:
Here is a list of popular medications containing diazepam as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:
|Trade name of the drug
||Pharmaceutical forms and doses
||Capsules; Oral; Diazepam 2 mgCapsules; Oral; Diazepam 5 mgCream; Rectal; Diazepam 0.2%Cream; Rectal; Diazepam 0.4%Enema; Rectal; Diazepam 5 mg / 2.5 mlEnema; Rectal; Diazepam 10 mg / 2.5 mlInjectable; Injection; Diazepam 5 mg / mlSolution; Rectal; Diazepam 5 mg / mlSolution; Rectal; Diazepam 5 mg / 2.5 mlSolution; Rectal; Diazepam 10 mg / 2.5 mlSuppositories; Rectal; Diazepam 5 mgSuppositories; Rectal; Diazepam 10 mgSyrup; Oral; Diazepam 2 mg / 5 mlTablets; Oral; Diazepam 2 mgTablets; Oral; Diazepam 5 mgTablets; Oral; Diazepam 10 mg
||ActavisAlpharmaAurobindoAurovitasBalkanpharmaC.T.S. Chemical IndustriesChemomedica Medizintechnik und ArzneimittelCSLDumexFaes FarmaInpac PharmaInstitute of Pharmaceutical Research and TechnologyIpsen PharmaMedinovaOrifarmPharmed Import & ExportPinewood LaboratoriesPrimal ChemicalRemekSanolaborSime Darby MarketingStadaTeam MedicaTeva
||Capsules; Oral; Diazepam 2 mgCapsules; Oral; Diazepam 5 mgDrops; Oral; Diazepam 1 mg / mlDrops; Oral; Diazepam 5 mg / mlDrops; Oral; Diazepam 10 mg / mlInjectable; Injection; Diazepam 5 mg / mlSolution; Oral; Diazepam 10 mg / mlSyrup; Oral; Diazepam 2 mg / 5 mlTablets; Oral; Diazepam 2 mgTablets; Oral; Diazepam 5 mgTablets; Oral; Diazepam 10 mg
||RocheAbbottCenexiDKSHInvesti FarmaNicholas PiramalOrifarmPiramal HealthcareZuellig Pharma
||Tablets; Oral; Diazepam 2 mgTablets; Oral; Diazepam 5 mg
||Arrow PharmaceuticalsAspenLuen Cheong Hong
Diazepam main article on Wikipedia: https://en.wikipedia.org/wiki/Diazepam
Diazepam compound on PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/Diazepam
Diazepam medicine on DrugBank: https://www.drugbank.ca/drugs/DB00829
Diazepam FAQ on MedlinePlus (revised 11/15/2020): https://medlineplus.gov/druginfo/meds/a682047.html
Diazepam Rectal FAQ on MedlinePlus (revised 11/15/2020): https://medlineplus.gov/druginfo/meds/a605033.html
Diazepam Nasal Spray FAQ on MedlinePlus (revised 11/15/2020): https://medlineplus.gov/druginfo/meds/a620026.html
Valium (Diazepam) tablets drug label info on DailyMed (revised November 8, 2019): https://dailymed.nlm.nih.gov/dailymed/drugInfo...
Diazepam injection solution drug label info on DailyMed (revised December 4, 2019): https://dailymed.nlm.nih.gov/dailymed/lookup...
Diazepam tablets drug label info on DailyMed (revised August 1, 2011): https://dailymed.nlm.nih.gov/dailymed/lookup...
Diazepam containing drugs on Drugs-About.com: https://drugs-about.com/ing/diazepam.html
Diazepam for sale on Pharma Doctor: https://pharma-doctor.com/diazepam.html
Diazepam international drug names on Drugs.com: https://www.drugs.com/international/diazepam.html
Valium (Diazepam) 2 mg, 5 mg, 10 mg tablets official prescribing information and medication guide from the U.S. FDA (revised March 2016): https://www.accessdata.fda.gov/drugsatfda_docs/label...
Valium (Diazepam) 2 mg, 5 mg, 10 mg tablets prescribing information and medication guide from Roche and Genentech pharmaceutical companies (revised February 2021): https://www.gene.com/patients/medicines/valium
Stesolid (Diazepam) rectal tubes 10 mg summary of product characteristics from Medicines.org.uk (revised June 2020): https://www.medicines.org.uk/emc/files/pil.104.pdf
Valpam (Diazepam) 2 mg, 5 mg tablets prescribing information from Arrow Pharma (revised September 2, 2014): http://www.arrowpharma.com.au/wp-content/uploads/1970/01/Valpam_PI.pdf
Diazepam 2 mg, 5 mg, 10 mg tablets package information leaflet from Accord Healthcare on Medicines.org.uk (revised August 2020): https://www.medicines.org.uk/emc/files/pil.4523.pdf
Revised: June 2021
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